Yoshitomo Yonetani (Food Wars! Shokugeki no Soma, Brave King GaoGaiGar) is directing the anime at J.C. Staff (The Disastrous Life of Saiki K., Little Busters!). Kazunori Iwakura (Aria the Scarlet Ammo, Ai Yori Aoshi) is designing the characters, and Seishi Minakami (A Certain Scientific Railgun, Heaven's Memo Pad) is in charge of series composition.
The novels center on Hiraga Josef Kō, a genius scientist, and Roberto Nicholas, an archives and cryptanalysis expert. The two work as a team as the Vatican's "miracle examiners," traveling the world to investigate the authenticity of claims of miracles.