1. Ui Hirasawa (K-ON!)
Preferences on how I want her to shut the hell up more often aside, I personally believe that Ui would have zero luck in being functional in the real world. It seems her only task in life is to feed her older sister Yui and tell her when to breathe and when not to over think while eating her toast, and without that, she simply can't do much outside of aimlessly wondering from senior center to senior center helping old folks. She may be fine if Yui were to also come to the real world along with her too, but I'd rather not that happen, simply because it'd be extra work for me to write a sad article on Japanator about a school shooting in Japan from people who get just as easily annoyed like we do. - See more at: http://orzzzz.com/top-10-goofy-anime-characters-with-absolutely-no-chance-in-real-life.html#sthash.inREWpxv.dpuf
2. Sawako Kuronuma (Kimi ni Todoke)
The charm from Kimi ni Todoke comes from knowing that no one in the world is as stupid and dense as Sawako. If I were to say that about a real-life representation of Sawako, I'd be asked to leave Japanator for making harsh remarks to a diagnosed mentally retarded girl.
And the funniest thing about it? Sawako isn't alone in being dumb when compared to the rest of the Kimi ni Todoke universe, such as Kazehaya and the students of Sawako's high school for not seeing how beautiful Sawako really is.
Well, at least Kazehaya has baseball as a back-up career in the real-world, and the students have functioning brains.