5. Minato Namikaze
Minato Namikaze was the 4th Hokage of Konoha. He was a very strong Shinobi, famous for his speeds. Minato was also a user of the Tailed Beast Mode during the war, and in this mode, he could atleast match up to Hashirama Senju easily.
4. Nagato Uzumaki
Nagato Uzumaki was Rinnegan user. If we consider him to be fully fit, he will wipe the floor with most Naruto Characters, which includes Hashirama Senju. A completely fit Nagato is just too strong for anyone to deal with.